Active fragments of fibroblast growth factor
US5387673A · kind A · utility
27Cited by
0References
6Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 26, 1993 |
| Grant date | Feb 7, 1995 |
| Priority date | — |
| Expiry date | Apr 26, 2013 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to novel fragments of basic fibroblast growth factor (bFGF). The mitogenic potency of one of these bFGF fragments, identified as HBF-2 is about 25-50 fold less than that of native bFGF but at least 10.sup.3 -10.sup.4 fold more active than that of previously reported synthetic fragments of bFGF. Therefore, the present invention provides the shortest fragment of bFGF that retains substantial biologic activity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.