Phosphonic peptide inhibitors of bacterial collagenases
US5389612A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Sep 23, 1992 |
| Grant date | Feb 14, 1995 |
| Priority date | — |
| Expiry date | Sep 23, 2012 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to novel derivatives of peptides usable as inhibitors of bacterial collagenases. These derivatives comply with the formula: ##STR1## in which R.sup.1 is an optionally substituted aryl or aralkyl group or the group ##STR2## with R.sup.6 being the side chain of an .alpha.-amino acid and R.sup.7 R.sup.8 a protective group or a radical derived from an amino acid or a protected peptide, R.sup.2 is derived from proline, hydroxyproline, thiazolidine or dehydroproline, R.sup.3 is H or an alkyl, and R.sup.4 is the side chain of an amino acid and R.sup.5 and R'.sup.5 are H, a metal, an alkyl or benzyl. The derivatives in which R'.sup.5 is a metal or hydrogen can be used as inhibitors of bacterial collagenases.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.