Transdermal therapeutical system with physostigmine as active component and process for the production thereof

US5391375A · kind A · utility

Assignees

• LTS Lohmann Therapie-Systeme GmbH Co. KG · DE
• Klinge Pharma GmbH · DE

Inventors

• Thomas Hille · Neuwied, DE
• Hans-Rainer Hoffmann · Neuwied, DE
• Hans-Joachim Huber · Hersbruck, DE
• Axel Knoch · Munich, DE
• Gerhard Schneider · Baldham, DE
• Fritz Stanislaus · Munich, DE

Key dates

• Filing date: Apr 26, 1993
• Grant date: Feb 21, 1995
• Expiry date: Apr 26, 2013

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P25/28
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to a transdermal therapeutical system for the administration of physostigmine to the skin via a backing layer which is impermeable to active substances, an active substance deposit comprising at least one auxiliary agent with supporting and distributing function in the form of a textile fabric material, a matrix surrounding said deposit from all sides, and optionally a removable protective layer, the matrix of which comprises 10-90%-wt polymeric material selected from the group consisting of polymers on the basis of acrylate and/or methacrylate and esters of hydrogenated colophonium, 0-30%-wt softener on the basis of hydrocarbons and/or esters, and that the active substance deposit immediately after its production comprises 15-85%-wt of a 0.1-70%-wt physostigmine solution.