Benzimidazolyl derivatives, pharmaceutical compositions containing these compounds and processes for preparing them

US5391556A · kind A · utility

Assignee

• Karl Thomae GmbH · DE

Inventors

• Armin Heckel · Biberach an der Riß, DE
• Robert Sauter · Biberach, DE
• Manfred Psiorz · Ingelheim am Rhein, DE
• Klaus Binder · Warthausen, DE
• Thomas Mueller · Zell am Harmersbach, DE
• Rainer Zimmermann · Mittelbiberach, DE

Key dates

• Filing date: Feb 8, 1993
• Grant date: Feb 21, 1995
• Expiry date: Feb 8, 2013

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D513/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to benzimidazolyl derivatives of general formula ##STR1## wherein R.sub.1 to R.sub.3 are defined as in claim 1, the mixtures of position isomers thereof and the salts thereof, which have valuable pharmacological properties, particularly the effect of extending the thrombin time, a thrombin inhibiting effect and an inhibiting effect on related serine proteases such as trypsin, pharmaceutical compositions containing this compound and processes for the preparation thereof.