Poly(sulfone-alpha-olefin) composite permselective membrane article for use in blood oxygenation
US5391580A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | May 10, 1993 |
| Grant date | Feb 21, 1995 |
| Priority date | — |
| Expiry date | May 10, 2013 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB01D71/68
- WIPO fieldChemical engineering
- WIPO sectorChemistry
Abstract
A biocompatable multi-layer article suitable for use in blood oxygenation is disclosed. The article is made up of a microporous polypropylene tube, a perm-selective, water vapor impermeable, carbon dioxide and oxygen permeable, homogeneous layer directly adhered to the polypropylene tube and active heparin linked through a covalent bond to the permselective layer. The polypropylene tube has an inside diameter from 240 to 400 .mu.m, a wall thickness from 10 to 50 .mu.m, and a porosity from 20 to 80 percent. The perm-selective layer is a polysulfone which has the structure ##STR1## where R is an alkyl group having 16 carbon atoms and n is 3,500 to 35,000. A method for producing a biocompatible multi-layer article suitable for use in blood oxygenation is also disclosed. The method involves the steps of immersing a microporous polypropylene tube which has an inside diameter from 240 to 400 .mu.m, a wall thickness from 10 to 50 .mu.m, and a porosity from 20 to 80 percent in a solution of a polysulfone which has the foregoing structure, and heating the coated polypropylene tube to a temperature that is above the softening point but below the decomposition temperature of the sulfone, e.g.…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.