Patent · US Expired

2-iodo-3-keto-.DELTA..sup.4 steroids, process for their production, as well as their further processing

US5391778A · kind A · utility

0Cited by

4References

9Claims

0Family size

Assignee

SCHERING CORPORATION · US

Inventors

Jurgen Westermann · Berlin, DE
Klaus Nickisch · Berlin, DE
Michael Harre · Berlin, DE
Ralph Rohde · Berlin, DE

Key dates

Filing date	Jan 11, 1993
Grant date	Feb 21, 1995
Priority date	—
Expiry date	Jan 11, 2013

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07J1/0074
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

The new intermediate products of general formula I ##STR1## in which R.sup.1 stands for a hydrogen atom or a straight-chain or branched alkyl group with 1 to 4 carbon atoms, PA1 R.sup.2 stands for a hydrogen atom or a methyl group, PA1 R.sup.3 stands for a hydrogen atom, PA1 R.sup.4 stands for an acyloxy group with 1 to 4 carbon atoms in the acyl radical or PA1 R.sup.3 and R.sup.4 together stand for a keto-oxygen atom, are suitable in an excellent way for introducing a .DELTA..sup.1 double bond in the steroid skelton with the simultaneous presence of a .DELTA..sup.4 double bond, as well as a saturated carbonyl group, by clevage of hydrogen iodide with a base in an amidic solvent at elevated temperature. If R.sup.2 stands for a hydrogen atom, the A-ring is aromatized after the hydrogen iodide cleavage. For the production of a new intermediate products, special iodization processes, which partially also allow a stereoselective control of the iodization, are used.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.