Estrogen-containing active substance plaster

US5393529A · kind A · utility

Assignees

• LTS Lohmann Therapie-Systeme GmbH Co. KG · DE
• Schwarz Pharma Ltd. · DE

Inventors

• Hans-Rainer Hoffmann · Neuwied, DE
• Robert-Peter Klein · Neuwied, DE
• Reinhold Meconi · Neuwied, DE
• Gunter Cordes · Leichlingen, DE
• Hans-Michael Wolff · Monheim, DE

Key dates

• Filing date: Jun 8, 1993
• Grant date: Feb 28, 1995
• Expiry date: Jun 8, 2013

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61L15/58
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to active substance plasters for the controlled release of active substances to the skin consisting of a backing layer, an adhesive film connected therewith which film is water-soluble and consists of pressure-sensitive adhesive which comprises water-swellable polymers and in which the active substance is at least partially soluble, and of a removable protective layer covering the adhesive film, in which plasters the pressure-sensitive adhesive is based on homo and/or copolymers with at least one derivative of the acrylic or methacrylic acid, and which comprise as active substances, partially or completely dissolved in the adhesive, at a concentration of 0.5 to 10.0%-wt estrogens and their pharmaceutically acceptable derivatives alone or in combination with gestagens.