Substituted dibenzoxazepine compounds for the treatment of convulsions, ischemia and other diseases responsive to prostaglandin-E.sub.2 antagonists
US5393747A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Nov 17, 1993 |
| Grant date | Feb 28, 1995 |
| Priority date | — |
| Expiry date | Nov 17, 2013 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F9/6527
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention provides methods for treating convulsions, ischemia and other diseases responsive to prostaglandin-E.sub.2 antagonists in an animal comprising administering a therapeutically-effective amount of a substituted dibenzoxazepine compound of Formula I, or a pharmaceutically-acceptable salt thereof, to the animal: ##STR1## wherein Y is oxygen, sulfur, --SO-- or --SO.sub.2 --, R.sup.1 is hydrogen, halogen or --CF.sub.3, R.sup.2 is hydrogen, halogen, --OH or --OCH.sub.3, R.sup.3 is hydrogen, alkyl, aryl, alkyl-substituted aryl or aryl-substituted alkyl, m is an integer of from 1 to 5, X is ##STR2## R.sup.4 is hydrogen, alkyl, aryl, alkyl-substituted aryl, trifluoromethyl-substituted aryl or aryl-substituted alkyl, and R.sup.5 and R.sup.6 are each independently hydrogen, alkyl, aryl, alkyl-substituted aryl or aryl-substituted alkyl.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.