Method for diagnosing rheumatoid arthritis
US5395753A · kind A · utility
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23Claims
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Key dates
| Filing date | Feb 19, 1993 |
| Grant date | Mar 7, 1995 |
| Priority date | — |
| Expiry date | Feb 19, 2013 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/102
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method is described for diagnosing rheumatoid arthritis by providing a recombinant IgM-specific rheumatoid arthritis-associated antigen and detecting antibodies against the antigen in patient sera. Preliminary steps of making a cDNA library from polyadenylated RNA purified from human cells, selecting recombinants that express the antigen, recloning cDNA containing the antigen gene in a high level expression vector, expressing the antigen in transformed cells, and purifying the antigen are also described.
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