Use of .sup.19 F magnetic resonance to non-invasively assess pO.sub.2 and temperature in vivo
US5397562A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jul 15, 1993 |
| Grant date | Mar 14, 1995 |
| Priority date | — |
| Expiry date | Jul 15, 2013 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T436/24
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Oxygen tension of tissue in a living subject may be determined non-invasively by a method which involves: administering to a living mammalian subject a biologically compatible perfluorocarbon emulsion in an amount effective to generate a measurable .sup.19 F spectrum under .sup.19 F NMR spectroscopy; allowing sufficient time to elapse for substantially all of the perfluorocarbon emulsion to be cleared from the vascular system of the subject, with a portion of the perfluorocarbon emulsion becoming sequestered in tissue of the subject; subjecting the tissue in which the perfluorocarbon emulsion has become sequestered to a .sup.19 F magnetic resonance spectroscopy procedure in which simultaneous measurements are made of spin-lattice relaxation rates for at least two separate resonances of the perfluorocarbon emulsion; and comparing the at least two spin-lattice relaxation rates measured in the .sup.19 F magnetic resonance spectroscopy procedure to a predetermined relation of spin-lattice relaxation rate to oxygen tension and temperature for the perfluorocarbon emulsion used, and thereby determining the oxygen tension and temperature of the tissue.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.