Correlated multi-dimensional chromatography with confirmatory hybrid run
US5398539A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Aug 2, 1993 |
| Grant date | Mar 21, 1995 |
| Priority date | — |
| Expiry date | Aug 2, 2013 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N30/8631
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
In a correlated two-dimensional gas chromatography system, it is necessary to "pair" peaks from one chromatogram with respective peaks of another chromatogram. Both peaks of a pair should correspond to the same sample component. The present invention provides for confirmation/disconfirmation of pairs that may be speculative or arbitrary. A hybrid chromatographic column is designed so that the retention time of a sample component is the average of the retention times of that component in the two independent columns. Thus, a peak location in the hybrid chromatogram can be calculated for each pair of peaks. The absence of a peak at that location or the inconsistency of the area of a peak at that location disconfirms the pairing. The invention also provides for higher dimensional systems and for other separation technologies.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.