Method for protein-liposome coupling
US5399331A · kind A · utility
162Cited by
5References
25Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 17, 1992 |
| Grant date | Mar 21, 1995 |
| Priority date | — |
| Expiry date | Sep 17, 2012 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention relates to a method for synthesizing a substantially pure reactive lipid including, for example, N-[4-(p-maleimidophenyl)-butyryl]phosphatidylethanolamine (MPB-PE) and related compositions. The compositions of the present invention are useful as coupling agents and may be incorporated into liposomes and subsequently coupled to proteins, cofactors and a number of other molecules. A preferred coupling method is also disclosed as are protein conjugates.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.