7-oxabicycloheptane carboxylic acid prostaglandin analog intermediates useful in the preparation of anti-thrombotic and anti-vasospastic compounds and method for preparing same

US5399725A · kind A · utility

Assignee

• Bristol-Myers Squibb Company · US

Inventors

• Michael A. Poss · Lawrenceville, US
• Paul D. Pansegrau · Lawrence, US
• Shaopeng Wang · Lawrence, US
• John K. Thottathil · Ivanhoe, US
• Janak Singh · Lawrenceville, US
• Richard H. Mueller · Marl, DE

Key dates

• Filing date: Apr 20, 1994
• Grant date: Mar 21, 1995
• Expiry date: Apr 20, 2014

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D493/08
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A method is provided for preparing carboxylic acid intermediates of the structure ##STR1## wherein an aldehyde of the structure ##STR2## is prepared and subjected to a Horner-Emmons reaction to form the ester of the structure ##STR3## and the ester is hydrogenated to the carboxylic acid which may be used in making the final anti-thrombotic--anti-vasospastic compounds.