Water insoluble non-magnetic manganese particles as magnetic resonance contract enhancement agents

US5401492A · kind A · utility

Assignee

• Sterling Winthrop Inc. · US

Inventors

• Kenneth Kellar · Wayne, US
• Piotr H. Karpinski · Lincoln Park, US
• Elaine Liversidge · West Chester, US
• Wolfgang H. H. Gunther · Hersbruck, DE
• Gregory L. McIntire · West Chester, US
• Barbara Van Orman · West Chester, US

Key dates

• Filing date: Dec 17, 1992
• Grant date: Mar 28, 1995
• Expiry date: Dec 17, 2012

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10T436/24
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention is directed to a magnetic resonance imaging composition for imaging of an organ rich in mitochondria comprising particles of a substantially insoluble manganese compound. In a preferred embodiment, the organ rich in mitochondria is the liver. In a further preferred embodiment, the particles are substantially nonmagnetic. In another preferred embodiment, the particles have a particle size of less than about 10 microns. In a still further preferred embodiment, the insoluble manganese compound is a manganese salt. The manganese compound is preferably selected from the group consisting of manganese phosphate, manganese carbonate and manganese 8-hydroxy quinolate. In another preferred embodiment, the composition of the present invention further comprises a surfactant. The present invention is also directed to a method of diagnosis comprising administering to a mammal a contrast effective amount of particles of a substantially insoluble manganese compound suspended or dispersed in a physiologically tolerable carrier and generating an NMR image of said mammal.