N-(1-thienylcycloalkyl)alkenylamines for treatment of neurotoxic injury
US5401755A · kind A · utility
3Cited by
1References
13Claims
0Family size
Assignees
Inventors
Key dates
| Filing date | Oct 8, 1991 |
| Grant date | Mar 28, 1995 |
| Priority date | — |
| Expiry date | Oct 8, 2011 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D333/20
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Compounds, compositions and methods of treatment are described to control brain damage associated with anoxia or ischemia which typically follows stroke, cardiac arrest or perinatal asphyxia. The treatment includes administration of an N-(1-thienylcycloalkyl)alkenylamine compound as an antagonist to inhibit excitotoxic actions at major neuronal excitatory amino acid receptor sites. Compounds of most interest are those of the formula ##STR1## wherein R.sup.1, R.sup.2, and R.sup.5 are defined in specification.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.