Methods for measuring perfusion using magnetic resonance imaging
US5402785A · kind A · utility
Assignees
Inventors
Key dates
| Filing date | Aug 16, 1991 |
| Grant date | Apr 4, 1995 |
| Priority date | — |
| Expiry date | Aug 16, 2011 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01R33/281
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Methods for measuring the perfusion of fluid in a substance are shown to include subjecting the fluid to electromagnetic energy so as to cause a response related to the magnetization of the fluid before it enters the substance, performing magnetic resonance measurements on the substance to generate intensity information and processing the intensity information to determine perfusion. In one embodiment of the invention, perfusion is measured by labeling atoms in the fluid at a base point, generating a steady state in the substance by continuing to label atoms until the effect caused by labeled atoms perfusing in the substance, reaches a steady state, generating image information for the substance and processing the image information to determine perfusion. It is preferred to label atoms by applying magnetic resonance perturbation. In one embodiment the labeling of atoms involves saturating spins associated with the atoms. In an especially preferred embodiment labeling involves inverting spins associated with the atoms continuously by adiabatic fast passage. Such inversion is preferably achieved by applying a radio frequency field virtually continuously. The invention is particularly…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.