Radiolabeled protein composition and method for radiation synovectomy
US5403573A · kind A · utility
6Cited by
13References
22Claims
0Family size
Assignee
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Key dates
| Filing date | Apr 23, 1992 |
| Grant date | Apr 4, 1995 |
| Priority date | — |
| Expiry date | Apr 23, 2012 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2121/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A radiolabeled protein composition adapted for radiation therapy which comprises a radioisotope and a protein material containing about 6 or more percent amino acids which have a sulfhydryl-containing side chain. A method for carrying out radiation synovectomy of arthritic joints. Rhenium radiolabeled protein microspheres are administered which contain cysteine and other amino acids. A method for radiolabeling a protein composition whereby the composition is treated with a reducing agent capable of reducing disulfides to sulfhydryls prior to radiolabeling.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.