Method for esterification of (S)-citronellol using lipase in supercritical carbon dioxide
US5403739A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Sep 10, 1993 |
| Grant date | Apr 4, 1995 |
| Priority date | — |
| Expiry date | Sep 10, 2013 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/54
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A primary terpene alcohol such as citronellol can be enzymatically esterified with a higher fatty acid such as oleic acid in the presence of lipase in an atmosphere of supercritical carbon dioxide as the reaction medium at a high reaction velocity. The influence of the temperature and pressure of the atmosphere on the reaction velocity was studied. When the starting primary terpene alcohol is a racemic compound of the optical isomers having chirality as in (.+-.)-citronellol, efficient racemic resolution can be achieved by suitably selecting the temperature and pressure in the vicinity of the critical point of carbon dioxide to give the (S)-(-)-ester having an optical purity of almost 100% when the starting terpene alcohol is (.+-.)-citronellol.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.