Use of bisphosphonates in endo-osteal bone surgery

US5403829A · kind A · utility

Assignee

• Leiras Oy · FI

Inventors

• Risto Lehtinen · Helsinki, FI
• Markku Nyman · Klaukkala, FI
• Pekka Paavolainen · Helsinki, FI

Key dates

• Filing date: Mar 24, 1993
• Grant date: Apr 4, 1995
• Expiry date: Mar 24, 2013

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61L2430/02
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A method of enhancing the formation of bone tissue and/or eliminating late complications subsequent to bone surgery comprising administering an amount, which is safe and sufficient to promote the formation of bone tissue and/or eliminate late complications, of a compound of formula ##STR1## wherein X is H, OH, Cl, F or a methyl group and Y is Cl, OH, --(CH.sub.2).sub.2 --N(CH.sub.3)--(CH.sub.2).sub.4 --CH.sub.3, --(CH.sub.2).sub.n --CH.sub.3 or --(CH.sub.2).sub.n --NH.sub.2, where n is zero or an integer of 1 to 8, --NHZ, where Z is pyridinyl or cycloheptyl, --SZ', where Z' is pyridinyl or chloro-substituted phenyl, or Y is a pyridinylsubstituted lower alkyl chain; or a non-toxic, pharmaceutically acceptable salt or ester thereof to a bone surgery patient.