Inclusion complexes of N-ethoxycarbonyl 1-3-morpholino-sydnonimine or salts formed with cyclodextrin-derivatives, preparation thereof and pharmaceutical compositions containing the same
US5403840A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jan 2, 1992 |
| Grant date | Apr 4, 1995 |
| Priority date | — |
| Expiry date | Jan 2, 2012 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D271/04
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to inclusion complexes of N-ethoxycarbonyl-3-morpholino-sydnonimine or its salts formed with a cyclodextrin derivatives, preparation thereof and pharmaceutical compositions containing the same. The inclusion complex of N-ethoxycarbonyl-3-morpholino-sydnonimine or its salt formed with cyclodextrin derivative is prepared by PA0 a) reacting the N-ethoxycarbonyl-3-morpholino-sydnonimine or its salt and the cyclodextrin derivative in a solvent medium, and if desired recovering the complex from the solution by dehydration, or PA0 b) high energy milling of the N-ethoxycarbonyl-3-morpholino-sydnonimine or its salt and the cyclodextrin derivative.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.