4-heterocyclophenyl-substituted dihydropyridines

US5403849A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Rudolf Schohe-Loop · Wuppertal, DE
• Wolfgang Hartwig · Wuppertal, DE
• Bodo Junge · Wuppertal, DE
• Heinrich Meier · Wuppertal, DE
• Zhan Gao · Beijing, CN
• Bernard Schmidt · Lindlar, DE
• Maarten de Jonge · Overath, DE
• Teunis Schuurman · Overath, DE

Key dates

• Filing date: Oct 22, 1993
• Grant date: Apr 4, 1995
• Expiry date: Oct 22, 2013

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D413/10
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

4-Heterocyclophenyl-substituted dihydropyridines ##STR1## are prepared either by reacting suitable aldehydes with amino esters and .beta.-keto esters, or preparing the heterocyclic substituents of the 4-phenyl by cyclization of corresponding amidines or hydrazides, or esterifying dihydropyridinecarboxylic acids, which are already substituted by heterocyclic radicals, with corresponding alcohols. The 4-heterocyclophenyl-substituted dihydropyridines can be employed in medicaments, in particular for treatment of diseases of the central nervous system.