Method for oral decorporation of metals
US5403862A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jan 17, 1992 |
| Grant date | Apr 4, 1995 |
| Priority date | — |
| Expiry date | Jan 17, 2012 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/195
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Several new powerful chelating agents, suitable for the removal of a variety of certain heavy metal ions from the body by oral application, have been synthesized and tested. Structurally, these compounds are partially lipophilic polyaminocarboxylic acids (PACA). They were synthesized in non-aqueous media from triethylenetetramine (TT) by monoalkylation of a primary amino group, followed by exhaustive carboxymethylation of the remaining amino groups using ethylbromoacetate and subsequent alkaline hydrolysis of the ester. Gel permeation chromatography of a mixture of the PACA and actinide elements have shown these substances to be strong chelating agents similar to EDTA or DTPA. In contrast to their non-lipophilic counterparts EDTA and DTPA, compositions of the present inventions exhibit appreciable absorption from the intestine and, therefore, can be administered orally. By varying the length of the alkyl chain, the chelons can be directed primarily to selected target organs. In addition, the compounds can be modified to target particular absorbed metals.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.