Single arm attached cyclodextrin polysiloxanes and use thereof as chiral stationary phases in chromatographic separation of enantiomers
US5403898A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Dec 7, 1993 |
| Grant date | Apr 4, 1995 |
| Priority date | — |
| Expiry date | Dec 7, 2013 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/54
- WIPO fieldChemical engineering
- WIPO sectorChemistry
Abstract
Cyclodextrin containing polymeric siloxanes wherein the cyclodextrin is connected to the polymeric siloxane by a single linking member connected to the 2, 3 or 6-position of the cyclodextrin are disclosed. These polymers are chemically and thermally stable to gas, supercritical fluid chromatographic conditions. The single arm attachment provides cyclodextrin containing polysiloxane polymers having synthesis reproducibility from batch to batch resulting in consistent chromatographic performance of the resulting chiral phases. The use of such polymers as chiral stationary phases in analytical and preparative gas, supercritical fluid and liquid chromatographic separations, and particularly for analysis of enantiomeric and other stereoisomeric mixtures of various substances is shown.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.