Vitamin B.sub.12 derivative, preparation process thereof, and use thereof
US5405839A · kind A · utility
13Cited by
0References
2Claims
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Assignee
Inventors
Key dates
| Filing date | Aug 11, 1993 |
| Grant date | Apr 11, 1995 |
| Priority date | — |
| Expiry date | Aug 11, 2013 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F15/065
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Vitamin B.sub.12 compounds, salts and pharmaceutical compositions containing said compounds represented by formula (I): ##STR1## wherein L, a ligand to the cobalt of the corrin ring, is selected from the group consisting of a cyano or adenosyl group, B is an imidazole group or a 5,6-dimethylbenzimidazole group, and R is a straight alkylene group having 1 to 8 carbon atoms, are disclosed. Methods for preparing compounds of Formula (I) as well as methods for using the compounds in in vitro assays, in cell growth studies and in in vivo studies using transplanted murine tumor cells are disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.