Tetracyclic antibiotics and processes for their preparation

US5405844A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Uwe Gerlach · Hattersheim, DE
• Rolf Horlein · Frankfurt am Main, DE
• Norbert Krass · Frankfurt am Main, DE
• Rudolf Lattrell · Königstein, DE
• Theo Wollmann · Hattersheim, DE
• Michael Limbert · Hofheim, DE
• Astrid Markus · Liederbach, DE

Key dates

• Filing date: May 28, 1992
• Grant date: Apr 11, 1995
• Expiry date: May 28, 2012

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D495/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Tetracyclic antibiotics and processes for their preparation .beta.-Lactam antibiotics of the formula I, and their pharmaceutically tolerable salts ##STR1## where X is (CH.sub.2).sub.0-2, CR(a)R(b), O, SO.sub.0-2 or NR(c), PA1 R1, R2 and R3 are a multiplicity of substituents, are outstanding antibiotics with remarkably good antibacterial activity both against gram-positive and against gram-negative microorganisms. They have a high stability to renal dehydropeptidase. They are obtained by cyclization of the compounds II ##STR2## or III ##STR3##