Process for the synthesis of glycosaminoglycans with heparin or heparan structure modified in position 2 of the .alpha.-L-iduronic-2-O-sulfate acid
US5405949A · kind A · utility
3Cited by
3References
8Claims
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Key dates
| Filing date | Mar 7, 1994 |
| Grant date | Apr 11, 1995 |
| Priority date | — |
| Expiry date | Mar 7, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC08B37/0075
- WIPO fieldMacromolecular chemistry, polymers
- WIPO sectorChemistry
Abstract
A process for the synthesis of glycosaminoglycans with heparin or heparan structure modified in position 2 of the .alpha.-L-iduronic-2-O-sulfate acid in which the sulfate group is, entirely or in part, substituted with a nucleophilic group, is described. The process is carried out by treating glycosaminoglycans having heparin or heparan structure with a nucleophilic reagent in alkaline solution.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.