Process for asymmetric total synthesis of camptothecin analogues
US5405963A · kind A · utility
4Cited by
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14Claims
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Assignee
Inventors
Key dates
| Filing date | Jun 10, 1993 |
| Grant date | Apr 11, 1995 |
| Priority date | — |
| Expiry date | Jun 10, 2013 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D491/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention provides a process for the asymmetric synthesis of camptothecin analogues as well as novel chemical intermediates of Formula I, II, and III. In general, the present process comprises conversion of a cis dioxolanone, having the same desired absolute configuration as the desired camptothecin analogue, to a compound of Formula I, II, or III, which compound is then converted to the desired camptothecin analogue. ##STR1##
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.