Methylen-oxindole derivatives compositions and tyrosine kinase inhibition therewith
US5409949A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Mar 12, 1993 |
| Grant date | Apr 25, 1995 |
| Priority date | — |
| Expiry date | Mar 12, 2013 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides new methylen-indole derivatives of formula (I) ##STR1## wherein R is a group ##STR2## in which R.sub.4 is hydrogen, hydroxy, C.sub.1 -C.sub.6 alkoxy, C.sub.2 -C.sub.6 alkanoyloxy, carboxy, nitro or NHR.sub.7, wherein R.sub.7 is hydrogen or C.sub.1 -C.sub.6 alkyl; PA1 R.sub.5 is hydrogen, C.sub.1 -C.sub.6 alkyl or halogen; and PA1 R.sub.6 is hydrogen or C.sub.1 -C.sub.6 alkyl; PA1 n is zero, 1 or 2; PA1 R.sub.1 is hydrogen, C.sub.1 -C.sub.6 alkyl or C.sub.2 -C.sub.6 alkanoyl; PA1 R.sub.2 is hydrogen, C.sub.1 -C.sub.6 alkyl, halogen, cyano, carboxyl, nitro or --NHR.sub.7 in which R.sub.7 is as defined above; PA1 R.sub.3 is hydrogen, C.sub.1 -C.sub.6 alkyl or C.sub.2 -C.sub.6 alkanoyl; and the pharmaceutically acceptable salts thereof; and wherein, when, at the same time, R.sub.2 is hydrogen, C.sub.1 -C.sub.6 alkyl, halogen or cyano and R.sub.3 is hydrogen, R.sub.1 and n being as defined above, then at least one of R.sub.4, R.sub.5 and R.sub.6 is other than hydrogen, which are useful as tyrosine kinase inhibitors.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.