Patent · US Expired

Method of producing a factor VIII preparation

US5410022A · kind A · utility

17Cited by

16References

26Claims

0Family size

Assignee

Immuno Aktiengesellschaft · AT

Inventors

Johann Eibl · Wien, AT
Friedrich Elsinger · Wien, AT
Herbert Gritsch · Wien, AT
Yendra Linnau · Wien, AT
Otto Schwarz · Waldshut-Tiengen, DE
Peter Turecek · Klosterneuburg, AT
Gunther Wober · Oberwaltersdorf, AT

Key dates

Filing date	Apr 20, 1993
Grant date	Apr 25, 1995
Priority date	—
Expiry date	Apr 20, 2013

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY10S530/831
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The invention relates to a method of producing virus-safe highly purified factor VIII. The method includes a combination of the following measures: PA1 a) chromatographic purification of a factor VIII-containing fraction, PA1 b) tenside treatment of factor VIII in an aqueous solution at a tenside/protein ratio of from 1:1 to 1000:1, and PA1 c) heat treatment of the factor VIII preparation in the solid state.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.