Process for the synthesis of glycosaminoglycans containing .alpha.-L-galacturonic acid substituted with nucleophilic groups in position 3
US5410039A · kind A · utility
9Cited by
3References
8Claims
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Key dates
| Filing date | Mar 7, 1994 |
| Grant date | Apr 25, 1995 |
| Priority date | — |
| Expiry date | Mar 7, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC08B37/0075
- WIPO fieldMacromolecular chemistry, polymers
- WIPO sectorChemistry
Abstract
A process for the synthesis of glycosaminoglycans in which one of the .alpha.-L-iduronic-2-O-sulfate acid saccharide units, which is characteristic of glycosaminoglycans with heparin or heparan structure, has undergone a structural modification, entirely or in part, with transformation into .alpha.-L-galacturonic acid substituted in position 3 with nucleophilic groups, is described. The process is carried out by treating glycosaminoglycans having heparin or heparan structure with a nucleophilic reagent in alkaline solution.
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