23-oxa-derivatives in the vitamin D series, process for their production, pharmaceutical preparations containing these derivatives as well as their use pharmaceutical agents

US5411949A · kind A · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Gunter Neef · Berlin, DE
• Andreas Steinmeyer · Berlin, DE
• Gerald Kirsch · Berlin, DE
• Katica Schwarz · Berlin, DE
• Martin Haberey · Berlin, DE
• Ruth Thieroff-Ekerdt · Concord, US
• Petra Rach · Berlin, DE

Key dates

• Filing date: Jul 19, 1993
• Grant date: May 2, 1995
• Expiry date: Jul 19, 2013

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P35/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

23-Oxa-derivatives in the vitamin D series of formula I ##STR1## are described in which R.sup.1, R.sup.2 and R.sup.4 independently of one another mean a hydrogen atom or an acyl group with 1 to 9 carbon atoms, PA1 R.sup.3 each means a hydrogen atom or each a linear or branched alkyl group with 1 to 4 carbon atoms and X means an alkylene radical--(CH.sub.2).sub.n -- with n=1, 2, 3, and if n=1, R.sup.3 each cannot be a methyl or propyl group, as well as a process for their production. The compounds have proliferation-inhibiting and cell-differentiation effects and are suitable for the production of pharmaceutical agents.