Chemoprotective isothiocyanates
US5411986A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Mar 12, 1993 |
| Grant date | May 2, 1995 |
| Priority date | — |
| Expiry date | Mar 12, 2013 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F9/4006
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Sulforaphane has been isolated and identified as a major and very potent phase II enzyme inducer in broccoli (Brassica oleracea italica). Sulforaphane is a monofunctional inducer, inducing phase II enzymes selectively without the induction of aryl hydrocarbon receptor-dependent cytochromes P-450 (phase I enzymes). Analogues differing in the oxidation state of sulfur and the number of methylene groups were synthesized, and their inducer potencies were measured. Sulforaphane is the most potent of these analogues. Other analogues having different substituent groups in place of the methylsulfinyl group of sulforaphane were also synthesized and assessed. Of these, the most potent are 6-isothiocyanato-2-hexanone and exo-2-acetyl-6-isothiocyanatonorbornane.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.