Enzymatic process to separate racemic mixtures of delta valerolactones

US5412110A · kind A · utility

Assignee

• Chemie Linz Gesellschaft m.b.H. · AT

Inventors

• Peter Pochlauer · Dordrecht, NL
• Marion Wagner · Katsdorf, AT

Key dates

• Filing date: Aug 28, 1992
• Grant date: May 2, 1995
• Expiry date: Aug 28, 2012

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12P41/004
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Process to separate racemic mixtures of beta-hydroxy or beta-acyloxy-delta-valerolactones, which in position 2 and/or 5 of the lactone ring are substituted by hydrogen, alkyl groups having 4 to 20 C atoms, which are optionally penetrated by an oxygen atom, or by aralkyl groups, whereby not both positions are substituted by hydrogen, through reaction of the racemic mixture in the presence of a hydrolase with or without esterifying agent in a diluent and separation of the reaction mixture, which contains an enantiomerically pure beta-hydroxy-delta-valerolactone and an enantiomerically pure beta-acyloxy-delta-valerolactone, through conventional methods into the enantiomically pure compounds, a process for the manufacture of enantiomerically pure oxetanones using said separation process and enantiomerically pure beta-acyloxy-delta-valerolactones.