Cocaine receptor binding ligands

US5413779A · kind A · utility

Assignees

• Research Triangle Institute · US
• The United States of America represented by the Secretary of Health and Human Services · US

Inventors

• Michael J. Kuhar · Baltimore, US
• Frank Ivy Carroll · Durham, US
• John W. Boja · Baltimore, US
• Anita H. Lewin · Chapel Hill, US
• Philip Abraham · Cary, US

Key dates

• Filing date: Mar 23, 1993
• Grant date: May 9, 1995
• Expiry date: Mar 23, 2013

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F7/2208
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

3.beta.-[4-iodophenyl]-tropan-2.beta.-carboxylic acid methyl ester tartrate is a high affinity binding ligand for cocaine receptors in mammalian brains. It and its congeners may be employed for imaging and other brain scanning techniques that allow the determination of the presence of cocaine receptors, such as dopamine and serotonin transporters and the like.