New leukotriene-B.sub.4 derivatives, process for their production and their use as pharmaceutical agents

US5414016A · kind A · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Werner Skuballa · Berlin, DE
• Bernd Buchmann · Hohen Neuendorf, DE
• Josef Heindl · Berlin, DE
• Wolfgang Frohlich · Berlin, DE
• Roland Ekerdt · Berlin, DE
• Claudia Giesen · Berlin, DE

Key dates

• Filing date: Jun 13, 1994
• Grant date: May 9, 1995
• Expiry date: Jun 13, 2014

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C69/732
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Leukotriene-B.sub.4 derivatives of formula I ##STR1## are described, in which R.sup.1 means CH.sub.2 OH, CH.sub.3, CF.sub.3, COOR.sup.5, CONR.sup.6 R.sup.7, or R.sup.1 together with R.sup.2 means a carbonyl group, R.sup.4 symbolizes H, C.sub.1 -C.sub.10 alkyl optionally substituted, C.sub.3 -C.sub.10 cycloalkyl, C.sub.6 -C.sub.10 aryl radical optionally substituted, or a 5-6-membered aromatic heterocyclic ring, A symbolizes a trans, trans-CH.dbd.CH--CH.dbd.CH, a --CH.sub.2 CH.sub.2 --CH.dbd.CH-- or a tetramethylene group, B symbolizes a C.sub.1 -C.sub.10 alkylene group, which optionally can be substituted by fluorine or the group ##STR2## D can mean a direct bond, oxygen, sulfur, --C.tbd.C--, --CH.dbd.CR.sup.6 or together with B can also mean a direct bond, their salts with physiologically compatible bases and their cyclodextrin clathrates.