Vinyl sulfone coupling of polyoxyalkylenes to proteins
US5414135A · kind A · utility
37Cited by
3References
14Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Nov 16, 1993 |
| Grant date | May 9, 1995 |
| Priority date | — |
| Expiry date | Nov 16, 2013 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N9/54
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A new class of polyalkylene oxide vinyl sulfone reagents is described. Also described are a method by which these reagents can be prepared as well as a method for using them in hydrated media for the modification of proteins. The novel polymer-to-protein conjugates made by reacting these reagents with proteins have advantages over similar conjugates prepared with prior art reagents in that they are more stable against hydrolysis and retain the positive charge carrying capacity at amine sites at which the modifying reagents are attached.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.