Antibodies which bind human collapsin
US5416197A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Oct 15, 1993 |
| Grant date | May 16, 1995 |
| Priority date | — |
| Expiry date | Oct 15, 2013 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K14/4703
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Essentially pure human collapsin and its uses are disclosed. An isolated nucleic acid molecule that comprises a nucleotide sequence that is complementary to a nucleotide sequence that encodes a portion of human collapsin is disclosed. Antibodies that specifically bind to human collapsin and that inhibit its activity are disclosed. Methods of inhibiting the activity of collapsin, methods of inducing neurite outgrowth and methods of treating individuals suffering from nerve damage comprising the step of contacting neuronal cells with nucleic acid molecule that comprises a nucleotide sequence that is complementary to a nucleotide sequence that encodes a portion of human collapsin or comprising the step of contacting a neuronal cell with an antibody that specifically binds to human collapsin are disclosed. Methods of identifying compounds that inhibit the activity of human collapsin comprising the steps of contacting a neuronal cell with human collapsin in the presence of a test compound are disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.