Patent · US Expired

Homologous recombination for universal donor cells and chimeric mammalian hosts

US5416260A · kind A · utility

62Cited by

0References

5Claims

0Family size

Assignee

The University of North Carolina at Chapel Hill · US

Inventors

Beverly Koller · Carrboro, US
Oliver Smithies · Durham, US

Key dates

Filing date	Nov 9, 1990
Grant date	May 16, 1995
Priority date	—
Expiry date	Nov 9, 2010

Classification

Technology area (CPC A)Human Necessities
CPC primaryA01K2267/03
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

Homologous recombination is employed to inactivate genes, particularly genes associated with MHC antigens. Particularly, the .beta..sub.2 -microglobulin gene is inactivated for reducing or eliminating Class I MHC antigens. The resulting cells may be used as universal donors. In addition, embryonic stem cells may be modified by homologous recombination for use in producing chimeric or transgenic mammalian hosts, which may be used as source of universal donor organs.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.