Composition containing enamel matrix from tooth germs for inducing binding between living mineralized tissue parts

US5418221A · kind A · utility

Assignee

• Bioventures N.V. · NL

Inventors

• Lars Hammarstrom · Djursholm, SE
• Leif Blomlof · Bad Füssing, DE
• Sven Lindskog

Key dates

• Filing date: Mar 24, 1994
• Grant date: May 23, 1995
• Expiry date: Mar 24, 2014

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K6/50
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Binding between parts of living mineralized tissue such as between a tooth and the jaw bone is induced with a composition containing mammalian enamel matrix isolated from tooth germs and a carrier such as water, and optionally an adhesive containing fibrinogen, factor XIII and thrombin. The enamel matrix is a precursor to tooth enamel and induces binding by forming cementum tissue. The enamel matrix may be obtained from bovine or porcine species. The composition is particularly applicable in dental therapies including loosening of teeth due to periodontitis, transplantation of teeth or in reintroduction of teeth disconnected by accident. The composition may also be used for healing of artificial implants such as tooth implants and implants of skeletal replacements such as artificial hip joints. In the case of a dislocated tooth, the composition is applied to a surface of the tooth root and the tooth is put back into its alveolus and lightly fixed for some weeks. In the treatment of periodontitis, a tooth root surface is exposed by incision, the surface is cleaned, the composition is applied to the cleaned root surface and the incision is closed and optionally stitched to promote he…