Method for lyophilization of cyclophosphamide and product
US5418223A · kind A · utility
12Cited by
3References
10Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 22, 1994 |
| Grant date | May 23, 1995 |
| Priority date | — |
| Expiry date | Apr 22, 2014 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K47/26
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A process for preparing a pharmaceutical preparation consisting essentially of a lyophilized cake of cyclophosphamide monohydrate and a bulking agent which comprises freezing cyclophosphamide, a bulking agent, and water, lyophilizing part of the water, obtaining and melting a supersaturated cyclophosphamide-bulking agent solution, precipitating cyclophosphamide as a hydrated polymorph, refreezing the solution and lyophilizing the water not bound to cyclophosphamide or the bulking agent.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.