Solid support for synthesis of 3'-tailed oligonucleotides
US5419966A · kind A · utility
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Key dates
| Filing date | Jul 12, 1993 |
| Grant date | May 30, 1995 |
| Priority date | — |
| Expiry date | Jul 12, 2013 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T428/2996
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A solid support for oligonucleotide synthesis has the structure ##STR1## where CPG represents a controlled pore glass matrix, the wavy line represents a carbon chain covalently linking the NH group with the controlled pore glass matrix, X is 2,2'-dimethoxytrityl or H, and R is alkyl, aryl, arylalkyl, heteroalkyl, or heteroaryl. The dimethoxytrityl group is removed from the solid support by treatment with acid, and the oligonucleotide is built, step-by-step in a conventional synthesizer after attachment of the 3' end of the first oligonucleotide unit to the hydroxyl function connected to the R group.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.