Antifungal polypeptide and process for its production

US5421839A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Norbert Ulbrich · Potsdam, DE
• Rolf Hilgenfeld · Friedrichsdorf, DE
• Heinz Hanel · Oberursel, DE
• Burkhard Sachse · Kelkheim, DE
• Peter Braun · Nieder-Olm, DE
• Joachim Wink · Rödermark, DE
• Peter Eckes · Kelkheim, DE
• Jurgen Logemann · Leiden, NL
• Jozef Schell · Neunburg vorm Wald, DE

Key dates

• Filing date: Oct 30, 1992
• Grant date: Jun 6, 1995
• Expiry date: Oct 30, 2012

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S530/823
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Antifungal polypeptide and process for its production The polypeptide with the sequence (SEQ ID NO: 1) Ala-Thr-Tyr-Asn-Gly-Lys-Cys-Tyr-Lys-Lys-Asp-Asn-Ile-Cys-Lys-Tyr-Lys-Ala-Gln -Ser-Gly-Lys-Thr-Ala-Ile-Cys- Lys-Cys-Tyr-Val-Lys-Lys-Cys-Pro-Arg-Asp-Gly-Ala-Lys-Cys-Glu-Phe-Asp-Ser-Ty r-Lys-Gly-Lys-Cys-Tyr-Cys can be produced by the fermentation of Aspergillus giganteus and used as an antifungal agent. Expression of this polypeptide gene in plants strongly inhibits the growth of phytopathogenic fungi on the plant.