Transdermal administration of amines with minimal irritation and high transdermal flux rate
US5422118A · kind A · utility
14Cited by
30References
22Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 21, 1992 |
| Grant date | Jun 6, 1995 |
| Priority date | — |
| Expiry date | Sep 21, 2012 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K47/14
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
An effective amount of a skin irritating physiologically active amine can be transdermally or topically administered in a minimally or nonirritating composition that maintains a suitably high transdermal flux rate, by providing the amine as a minimally or nonirritating salt of a stoichiometric molar excess of a fatty acid of from 8 to 20 or 22 carbon atoms, in a nonpolar, nonvolatile solvent.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.