2,3-disubstituted isoxazolidines, agents containing them and their use

US5422342A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Stephan Henke · Bad Soden am Taunus, DE
• Dietrich Brocks · Wiesbaden, DE
• Volkmar Gunzler · Marburg, DE

Key dates

• Filing date: Apr 16, 1993
• Grant date: Jun 6, 1995
• Expiry date: Apr 16, 2013

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K5/0819
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The invention relates to compounds of the formula ##STR1## in which A denotes an optionally substituted radical from the series comprising alkyl, acyl, cycloalkyl, aryl and heteroaryl; A.sub.1 represents CO, CS, C=NH, CN-alkyl, CN-O-alkyl, SO, optionally substituted CH.sub.2 or a bond; A.sub.2 represents NH, NCH.sub.3, O, CH.sub.2 or a bond; E represents CHOH, CO, SO or optionally N-substituted C=NH; A.sub.3 represents O, NH, NCH.sub.3 or a bond; R.sup.4 denotes an optionally substituted radical from the series comprising alkyl, cycloalkyl, aryl and heteroaryl; and R.sup.8 denotes hydrogen or optionally substituted alkyl, to a process for their preparation, and to their use as inhibitors of prolyl hydroxylase.