Immunization against babesiosis using purified surface antigens of Babesia bigemina and similar immunogens
US5422428A · kind A · utility
5Cited by
3References
4Claims
0Family size
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Key dates
| Filing date | Dec 6, 1991 |
| Grant date | Jun 6, 1995 |
| Priority date | — |
| Expiry date | Dec 6, 2011 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/855
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Antigenic surface proteins from the intraerythrocytic merozoite stage of Babesia bigemina have been isolated using cell fusions and monoclonal antibodies produced thereby. The gene encoding a 58 kD surface protein has been identified and the DNA sequence determined and compared with sequences of other known merozoite proteins. Immunization of mammals, such as bovines, with purified isolates induces an immunological response that is effective to reduce pathological effects of babesiosis induced by Babesia bigemina. Diagnostic kits using monoclonal antibodies and antigenic surface proteins of Babesia bigemina are also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.