Amyloidin protease and uses thereof
US5424205A · kind A · utility
Assignees
Inventors
Key dates
| Filing date | May 7, 1993 |
| Grant date | Jun 13, 1995 |
| Priority date | — |
| Expiry date | May 7, 2013 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N9/6421
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A proteolytic enzyme isolated from human tissue which exhibits a proteolytic activity to hydrolyze Met-Asp peptide bond in an amyloid-like substrate is disclosed. This enzyme has been designated "amyloidin" because it proteolytically cleaves a Met-Asp bond similar to the one present in the amyloid precursor protein to release a fragment having the mature Asp terminus of the .beta.-amyloid peptide. Antibodies to the amyloidin protease are also provided. Methods to isolate and purify the amyloidin protease are provided, as well as assays to screen for inhibitors of the amyloidin protease. Also disclosed is the gene encoding the protease and methods for expression of the protease by recombinant DNA means.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.