Isosteric peptides
US5424291A · kind A · utility
3Cited by
1References
14Claims
0Family size
Inventors
Key dates
| Filing date | Aug 10, 1994 |
| Grant date | Jun 13, 1995 |
| Priority date | — |
| Expiry date | Aug 10, 2014 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Compounds of formula I relate to the peptide sequence of human fibrogen A.alpha. chain, with modified positions 14 through 17 (P.sub.3 -P.sub.1.sup.1), which may be a useful inhibitor of thrombin. The antithrombin and anticoagulant compounds of this invention, therefore, have therapeutic potential in treatment or prophylaxis of thrombosis and related atherosclerotic diseases. A procedure for the synthesis of peptides according to formula I is also described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.