Process for the preparation of a stable factor VIII

US5424401A · kind A · utility

Assignee

• Behringwerke Aktiengesellschaft · DE

Inventors

• Norbert Heimburger
• Klaus Wellner · Marburg, DE
• Karl-Heinz Wenz · Argenstein, DE
• Gerhardt Kumpe · Wetter, DE

Key dates

• Filing date: Dec 14, 1993
• Grant date: Jun 13, 1995
• Expiry date: Dec 14, 2013

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K14/755
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

A process for the preparation of a pasteurized factor VIII concentrate with high specific activity and stability is described, which comprises adsorbing impurities from the solution containing the factor VIII by at least two-fold adsorption with Al(OH).sub.3, an anion exchanger or Ca.sub.3 (PO.sub.4).sub.2, preferably with two different adsorbents from this group.