Fluorescent benzothiazole derivatives
US5424440A · kind A · utility
28Cited by
10References
12Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Nov 24, 1993 |
| Grant date | Jun 13, 1995 |
| Priority date | — |
| Expiry date | Nov 24, 2013 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q2334/00
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Novel benzothiazole derivatives having a fluorescence inhibiting group linked by an enzyme cleavable bond and methods for their synthesis are provided. Upon cleavage of the enzyme-cleavable bond, a strongly fluorescent reaction product is produced. These compounds may be used to detect enzymatic activity. The fluorescent reaction products are detectable at an attomolar level using a fluorometer.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.