Arylsulphonamides, pharmaceutical compositions containing these compounds

US5426119A · kind A · utility

Assignee

• Dr. Karl Thomae GmbH · DE

Inventors

• Armin Heckel · Biberach an der Riß, DE
• Josef Nickl
• Rainer Soyka · Biberach, DE
• Wolfgang Eisert · Biberach, DE
• Thomas Müller · Biberach, DE
• Johannes Weisenberger · Biberach, DE
• Christopher Meade · Bingen, DE
• Gojko Muacevic · Ingelheim am Rhein, DE

Key dates

• Filing date: Nov 18, 1993
• Grant date: Jun 20, 1995
• Expiry date: Nov 18, 2013

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D409/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to new arylsulphonamides of the formula ##STR1## (wherein A, B and R.sub.1 to R.sub.6 are as defined in claim 1, the enantiomers, the cis- and trans-isomers thereof where R.sub.4 and R.sub.5 together represent a carbon-carbon bond, and the addition salts thereof, more particularly for pharmaceutical use the physiologically acceptable addition salts thereof with inorganic or organic bases, if R.sub.6 represents a hydroxy group) which have useful pharmacological properties, particularly antithrombotic activities and thromboxane-mediating activities. Furthermore, the new compounds are also thromboxane antagonists (TRA) and thromboxane synthesis inhibitors (TSH). They also have an effect on PGE.sub.2 production.